Narendra Kumar
Associate Professor of Pharmaceutical Sciences
Contact
Texas A&M Irma Lerma Rangel School of Pharmacy
1010 W. Ave. B
Kingsville,
TX
78363
narendra08@tamu.edu
Phone: 361.221.0743
Fax: 361.221.0793
Narendra Kumar Lab
Education and Training
- Indian Institute of Technology, India, PhD, Microbial Biotechnology
- Goa University, India, Master of Science in Marine Biotechnology
Research Interests
- Chronic mucosal inflammation leads to different complications such as Ulcerative Colitis, Crohn’s disease, Alzheimer’s disease, biliary cholangitis, and epithelial cancer. The research focus is to determine the interorgan communication and find therapeutic targets through dissecting the molecular determinants that regulate mucosal inflammation through three major approaches.
- In-vitro analysis of the structure and functions of the molecular determinants
- Ex-vivo confirmation of the proof of the principle in a primary cell and organoid culture
- In-vivo amelioration of mucosal inflammation through targeted gene and drug delivery
Teaching Interests
- Microbiology/Immunology
- Biochemistry
- Integrated pharmacotherapy for IBD and SLE
- Biotechnology
- Biotech drug and vaccine product development
Awards, Recognition and Service
- Member, Crohn's and Colitis Foundation of America (CCFA) Novel technology workgroup on Challenges in Inflammatory Bowel Disease (IBD). 2023.
- Member, International board of studies of School of Biotechnology “Kalinga Institute of Industrial Biotechnology”. 2021-2024.
- Member, National Institutes of Health (NIH) Center for Scientific Review (CSR) “Impact of anonymization on NIH peer review outcomes”. 2020.
- Artificial Intelligence Molecular Simulation (AIMS) Award. 2019 • Distinguished Faculty Award, the Coastal Bend Society of Health System Pharmacists June 2, 2018.
- American Association of Colleges of Pharmacy (AACP) Research Leadership Fellow 2018
- Member, NIH, Gastrointestinal Mucosal Pathobiology (GMPB) Study Section. 2016.
- CCFA Research Fellowship Award Awarding agency: Crohn's and Colitis Foundation of America (CCFA). Award Period: July 2005 to December 2008.
- AGA-Research Scholar Award, Awarding agency: American Gastroenterology Association (AGA)’s Foundation for Digestive Disease. Award Period: July, 2009-June, 2012 (returned due to funding of KO1 as guidelines).
- “CCFA Career Development Award,” Awarding agency: Crohn’s and Colitis Foundation of America (CCFA). Award Period: January 2009 to December 2011.
- “NIH Basic Scientist Career Development Award (KO1),” Awarding agency: National Institute of Health (NIH) Award Period: September 2009 to May 2014.
- Certificates/other awards by academic institutions: “Certificate of Appreciation,” for securing the most Federal research funds. Awarding agency: Department of Pharmaceutical Sciences, ILR College of Pharmacy, Texas A&M Health Science Center, 2009.
- “Certificate of Felicitation” for invited presentation at “World Congress on Gastroenterology and Urology.” Awarding agency: Omics Publishing Group, Calif. March 2012.
- “Faculty Mentor Award” for Upward Bound Math & Science program. Awarding agency: Texas A&M Kingsville, July 12, 2012.
- “Certificate of Recognition” for McNair Scholar program. Awarding agency: Texas A&M Kingsville, Oct. 18, 2012.
- “CCFA Travel Award,” Awarding agency: Crohn’s and Colitis foundation of America, Purpose: to attend “Junior Faculty Symposium on Inflammatory Bowel Disease” held at the Johns Hopkins University, Baltimore, Md. May 10-11, 2005.
- “CCF-CCFA Travel Award.” Awarding agency: Cleveland Clinic Foundation (CCF) and Crohn’s and Colitis Foundation of America (CCFA), Purpose: to attend Inflammatory Bowel Disease Summit at MBNA Conference Center Cleveland, OH. Award period: Oct. 4-7, 2006.
- “AGA-BSG Stem Cell Scholarship”, Awarding agency: American Gastroenterology Association and British Society of Gastroenterology, Purpose: to present research at “Stem Cells in Gastrointestinal Development, Regeneration and Neoplasia Symposium” held at Tyson Corner, Va. Award period: Sept. 8-9, 2006.
- “AGA Institute Travel Award,” Awarding agency: American Gastroenterology Association (AGA), Purpose: to attend AGA Institute Academic Skills Workshop Miami, FL. Award Period: Feb. 9-10, 2007.
- “Doctoral Research Scholarship Award”, Awarding agency: the Department of Human Resource Development Government of India. Purpose: awarded through national scholarship tests, “Graduate Aptitude Test in Engineering “GATE, for the entire period of graduate studies Award period: January 1997 to June 2001.
- “DST Foreign Travel Award,” Awarding agency: the Department of Science and Technology Govt. of India, purpose: to present research at the “9th European Congress on Biotechnology (ECB9)” Brussels, Belgium. Award period: July 11-15, 1999.
- “Department of Biotechnology National Scholarship Award” Awarding agency: the Department of Biotechnology, Govt. of India. Purpose: for Master of Science studies in Marine Biotechnology. Award period: July 1994 to June 1996.
- Certificate of Merit; All India Graduate Aptitude Test in Engineering (GATE), 1996 All India Rank-163.
Patents
- Kumar N, Das D. Production of pollution free gaseous fuel. IPA# 464/ Cal/2001 DT. 21.8.2001/India.
- Kumar N, Das D. Development of a high rate and yield hydrogen production process. IPA 665/Cal/2001 DT.04.12.2001/India.
- Kumar N, and Mishra J. A Novel High Throughput Assay for finding new Jak3 Interacting Compounds, Biomolecules, and Inhibitors. US Non-Provisional patent number US 14/483,622; US20150344934 A1. (Under negotiation for licensing).
- Kumar N, and Mishra J. Methods of Screening for Janus Kinase 3 Interacting Compounds. United States Patent. Patent No.: US 9,739,779. Date of award: Aug 22, 2017.
- Kumar N, and Mishra J. Biomarkers for Early Detection of Colorectal Cancer. TAMU- HSC. No.: 4812HSC18. Date: September 11, 2018.
- Kumar N, and Mishra J. Sweat test based non-invasive diagnosis for lung cancer. TAMU- HSC. No.: 6292HSC23. Date: June 21, 2023.
- Kumar N, and Mishra J. Smart drug for lung cancer. TAMU- HSC. No.: 6294HSC23. Date: June 21, 2023.
- Kumar N, and Mishra J. Jak3-SH2 domain targeted a new class drug for metastatic lung cancer. TAMU- HSC. No.: 6293HSC23. Date: June 21, 2023.
- Mishra J, and Kumar N. AI-based new class of Jak3-targeted drugs for triple-negative breast cancer metastasis. TAMU- HSC. No.: 6295HSC23. Date: June 21, 2023.
- Kumar N, and Mishra J. Jak3-SH2 domain targeted new class drug for metastatic triple-negative breast cancer brain-metastasis. TAMU- HSC. No.: 6296HSC23. Date: June 21, 2023.
Representative Publications
- Kumar P, Mishra J, Kumar N. Mechanistic Role of Jak3 in Obesity-Associated Cognitive Impairments. 2022 Sep 9;14(18):3715 PMID: 36145091
- Mishra J, Stubb M, Kuang L, Vara N, Kumar P, Kumar N. Inflammatory Bowel Disease Therapeutics; A focus on Probiotic Engineering. Mediators Inflamm. 2022 Jan 15 (1); PMID:35082553.
- Kumar N , Surani S, Udeani G, Mathew S, John S, Sajan S, Mishra J. Drug-induced liver injury and prospect of cytokine based therapy; A focus on IL-2 based therapies. Life Sci. 2021 May 1; 278:119544. PMID: 33945827
- Kumar N, Kuang L, Villa R, Kumar P, Mishra J. Mucosal Epithelial Jak Kinases in Health and Diseases. Mediators Inflamm. 2021 Mar 16;2021: 6618924. PMID: 33814980
- Mishra J, Simonsen R, Kumar N. Intestinal breast cancer resistance protein (BCRP) requires Janus kinase 3 activity for drug efflux and barrier functions in obesity. J Biol Chem. 2019 Nov 29;294(48):18337-18348. PMID: 31653704
- Mishra J, Das JK, Kumar N. (2017). Janus kinase-3 regulates adherens junction and epithelial mesenchymal transition through β-catenin. J. Biol. Chem. 292(40) 16406–19. PMID: 26451047.
- Mishra J, Verma RK, Alpini G,Meng F, Kumar N. (2015). Role of Janus Kinase 3 in Predisposition to Obesity-associated Metabolic Syndrome. J Biol Chem. 4;290 (49):29301- 12. PMID: 26451047.
- Mishra J, Kumar N. (2014). Adapter protein SHC regulates JANUS kinase 3 phosphorylation. J Biol Chem. 2014 May 2. PMID: 24795043. (Report)
- Mishra J, Verma RK, Alpini G,Meng F, Kumar N. (2013). Role of Janus Kinase 3 in Mucosal Differentiation and Predisposition to Colitis. J. Biol. Chem. 288 (44):31795-806. PMID:24045942
- Mishra J, Drummond J, Karanki SS, Quazi S, and Kumar N. (2013). Prospective of Colon Cancer Treatments and Scope for Combinatorial Approach for Enhanced Cancer Cell Apoptosis. Crit Rev Oncol Hematol., 86, 232-250, PMID: 23098684.
For complete list of publications follow: Publications