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Scholarly Work

Scholarly Work

Selected Peer Reviewed Publication:

  • Rachel Dopart, Sri Sujana Immadi, Dai Lu, Debra A. Kendall (2020). Structural Optimization of the Diarylurea PSNCBAM-1, an Allosteric Modulator of Cannabinoid Receptor 1, Current Therapeutic Research, (92) 100574.

  • Mohammed Mustafa, Giulia Donvito, Lauren Moncayo, Justin Poklis, Ralph, Grauer, Teresa Olszewska, Debra Kendall, Dai Lu, Aron Lichtman. (2019) In vivo evaluation of the CB1 allosteric modulator LDK1258 reveals CB1 receptor independent behavioral effects, Pharmacology Biochemistry and Behavior (190) 172840, 2019.

  • Lu D, Immadi SS, Wu Z, Kendall DA. Translational potential of allosteric modulators targeting the cannabinoid CB 1 Acta Pharmacologica Sinica. 2019; 40(3):324-335. PubMed [journal] PMID: 30333554

  • Jagla CAD, Scott CE, Tang Y, Qiao C, Mateo-Semidey GE, Yudowski GA, Lu D, Kendall DA (2019). Pyrimidinyl Biphenylureas Act as Allosteric Modulators to Activate Cannabinoid Receptor 1 and Initiate β-Arrestin-Dependent Responses. Molecular pharmacology. 95(1):1-10. PubMed [journal] PMID: 30322873, PMCID: PMC6277924

  • Immadi SS, Dopart R, Wu Z, Fu B, Kendall DA, Lu D. Exploring 6-Azaindole and 7-Azaindole Rings for Developing Cannabinoid Receptor 1 Allosteric Modulators. Cannabis and cannabinoid research. 2018; 3(1):252-258. PubMed [journal] PMID: 30547095, PMCID: PMC6290480

  • Khurana L, Fu BQ, Duddupudi AL, Liao YH, Immadi SS, Kendall DA, Lu D*. (2017) Pyrimidinyl Biphenylureas: Identification of New Lead Compounds as Allosteric Modulators of the Cannabinoid Receptor CB1, J. Med. Chem. 60(3):1089-1104.

  • Qiao CJ, Ali HI, Ahn KH, Kolluru S, Kendall, DA, Lu D*. (2016) Synthesis and biological evaluation of indole-2-carboxamides bearing photoactivatable functionalities as novel allosteric modulators for the cannabinoid CB1 receptor, Eur. J. Med. Chem. 121:517-529

  • Lu D, Wei HX, Zhang J, Gu Y, Osenkowski P, Ye W, Selkoe DJ, Wolfe MS, Augelli-Szafran CE. (2016) Part 1: Notch-sparing γ-secretase inhibitors: The identification of novel naphthyl and benzofuranyl amide analogs, Bioorg. Med. Chem. Lett. 26(9):2129-32.

  • Wei HX, Lu D, Sun V, Zhang J, Gu Y, Osenkowski P, Ye W, Selkoe DJ, Wolfe MS, Augelli-Szafran CE. (2016) Part 2. Notch-sparing γ-secretase inhibitors: The study of novel γ-amino naphthyl alcohols, Bioorg. Med. Chem. Lett. 26(9):2133-2137.

  • Zhang J, Lu D, Wei HX, Gu Y, Selkoe DJ, Wolfe MS, Augelli-Szafran CE. (2016) Part 3: Notch-sparing γ-secretase inhibitors: SAR studies of 2-substituted aminopyridopyrimidinones, Bioorg. Med. Chem. Lett. 26(9):2138-2141

  • Mahmoud MM, Olszewska T, Liu H, Shore DM, Hurst DP, Reggio PH, Lu D, Kendall DA (2015) (4-(Bis(4-fluorophenyl)methyl)piperazin-1-yl)(cyclohexyl)methanone hydrochloride (LDK1229): a new cannabinoid CB1 receptor inverse agonist from the class of benzhydryl piperazine analogs. Mol. Pharmacol. 87(2) 197-206. (doi: 10.1124/mol.114.095471)

  • Leepakshi K., Ali, HI, Olszewska T., Ahn, K., Damaraju A., Kendall D., Lu, D*. (2014) Optimization of Indole-2-carboxamides Reveals Key Structure Activity Relationships for Allosteric Modulation of the Cannabinoid Receptor 1 (CB1). J Med Chem 57(7) 3040-52, (DOI: 1021/jm5000112).

  • Mahmoud MM, Ali HI, Ahn KH, Damaraju A, Samala S, Plalaputhi, VK, Kolluru S, Kendall DA, Lu D.* (2013) Structure activity Relationship Study identifies a Potent Allosteric modulator for CB1 receptor. J Med Chem 56 (20) 7965-75.

  • Ahn KH, Mahmoud MM, Samala S, Lu D.*, Kendall DA. (2013) Profiling two indole-2-carboxamides for allosteric modulation of the CB1 receptor. J Neurochem. 124, 584-9

  • Lu, D., Guo, J-X., Duclos, R.I. Jr, Bowmann, A., Makriyannis, A., (2008) Bornyl and Isobornyl-∆ 8-tetrahydrocaabinol: A novel class of cannabinergic ligands, J. Med. Chem. 51, 6393-99.

  • Guo, J-X., Yang, D.P., Chari. R., Tian, X-Y., Pavlopoulos, S., Lu, D., Makriyanni,s A.(2008) Magnetically Aligned Bicelles to Study the Orientation of Lipophilic Ligands in Membrane Bilayers, J. Med. Chem. 51, 6793-6799

  • Khanolkar, A.D., Lu, D., Ibrahim, M., Duclos, R.I. Jr, Thakur, G.A., Malan T.P., Jr, Porreca, F., Veerappan, V., Tian, X-Y., George, C., Parrish, D.A., Papahatjis, D.P., Makriyannis, A. (2007) Cannabilactones: A novel class of CB2 selective agonists with peripheral analgesic activity, J. Med. Chem. 50, 6493-6500

  • Lu, D, Meng, Z.X., Thakur, G.A., Fan, P., Steed, J., Tartal, C.L., Hurst, D.P., Reggio P.H., Deschamps, J.R., Parrish, D.A., George. C., Järbe, T.U., Lamb, R.J., Makriyannis, A. (2005) Adamantyl Cannabinoids: A Novel Class of Cannabinergic Ligands. J. Med. Chem. 48, 4576-85.

  • Guo, J., Pavlopoulos, S., Tian, X., Lu, D., Nikas, S.P., Yang, D.P., Makriyannis, A. (2003) Conformational Study of Lipophilic Ligands in Phospholopid Model Membrane System by Solution NMR”. J. Med. Chem. 46, 4838-46.

  • Liu, Q., Wang, D.H., Li, C., Lu, D., Wang, W.J., Guo, J.Y. (2003) “Synthesis and CNS activities of alpha-agarofuran derivatives. Chin. J. Med. Chem. 13, 125-30.

  Google Scholar Dai Lu

 

Drug Discovery Patents:

  • Dai Lu, Changjiang Qiao, Boqiao Fu, Anantha Lakshmi Duddupudi, Zhixing Wu. “Functionalized Pyrano[2,3- d]Pyrimidin-7-one Derivatives and Methods For Their Preparation And Use”. US 62/340,393, 2016. WO2017/205432.

  • Corinne Augelli-Szafran, Dai Lu, HanXun Wei, Jing Zhang, Michael Wolfe, Dennis Selkoe, CuiMan Cai, “Novel Sulfonamides”, WO2013/052700, US 61/543,287, 2013

  • Corinne Augelli-Szafran, Dai Lu, HanXun Wei, Jing Zhang, Michael Wolfe, Dennis Selkoe, “Sulfonamide-Containing Compounds”, WO2012/047926, US 61/389,537, 2012

  • Alexandros Makriyannis, Chen Li, Dai Lu, “Cannabinergic Lipid Ligands”. WO/2006/044381, PCT/US2003/026609, U.S. Patent: 8,202,893 B2, 2012.

  • Alexandros Makriyannis, Spyros Nikas, Atmaram Khanolkar, Ganesh A. Thakur, Dai Lu, “Bicyclic cannabinoids” US Patent No. 7446229, 2008

  • Alexandros Makriyannis, Dai Lu, “Keto Cannabinoids with Therapeutic Indications”. WO/2004/017922, PCT/US2003/026609; U.S. Patent: 7183313, 2007.

  • Alexandros Makriyannis, Dai Lu, Atmaram Khanolkar, “Novel Analgesic and Immunomodulatory Cannabinoids”. International Patent Application, PCT/US99/09701, 2001, US Patent: 6939977, 2005.

  • Alexandros Makriyannis, Xin-Zhong Lai, Dai Lu, “Novel Biphenyl and Biphenyl-Like Cannabinoids”. PCT/US2003/026585, 2003; US Patent: 0087590, 2004

  • Alexandros Makriyannis, Atmaram Khanolkar, Dai Lu, “Novel Cannabinoids Selective for the CB2 Receptor”. PCT/US99/09806, 2001, U.S. Patent: 6,166,066. 2000

 

Book Chapters:

  • Lu, D.*; Potter, D. E. Cannabinoids and the Cannabinoid Receptors: An Overview. In Handbook of Cannabis and Related Pathologies, 1st ed.; Preedy, V. R., Ed. Academic Press: London, United Kingdom, 2017; pp 553-563.

  • Lesley D Schurman, Dai Lu, Debra A Kendall, Allyn C Howlett, Aron H Lichtman, Molecular mechanism and cannabinoid pharmacology in Substance Use disorders, Part of the Handbook of Experimental Pharmacology. Springer, Berlin, Heidelberg, 2019: pp323-353.