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Lin Zhu

Lin Zhu
Lin Zhu, PhD

Associate Professor of Pharmaceutical Sciences

Contact

Texas A&M Irma Lerma Rangel School of Pharmacy
1010 W. Ave. B
Kingsville, TX 78363
lzhu@tamu.edu
Phone: 361.221.0757
Fax: 361.221.0793
Lin Zhu's Lab

Education and Training

  • Northeastern University, School of Pharmacy, American Cancer Society Postdoctoral Fellow, 2013
  • Northeastern University, School of Pharmacy, Postdoctoral Research Associate, 2010-2012
  • University of Tennessee Health Science Center, PhD, Pharmaceutics, 2010
  • China Pharmaceutical University, China, Master of Science, Pharmaceutics, 2003
  • China Pharmaceutical University, China, Bachelor of Engineering, Pharmaceutics, 1997

Research Interests

  • Development of novel drug delivery systems and nanomedicine for small and macro molecules.
  • Design and synthesis of functional polymers/conjugates for drug delivery.
  • Targeted and stimulus-responsive delivery of therapeutic and imaging agents.
  • In vitro and in vivo characterization of drug delivery systems/therapeutics.
  • Cancer therapy.

Teaching Interests

  • Pharmaceutics
  • Dosage forms and drug delivery systems
  • Biopharmaceutics
  • Pharmacokinetics
  • Nanomedicine

Awards, Recognition and Service

  • NIH/NCI R15 Award. Title: Improving tumor specificity and overcoming drug resistance of proteasome inhibitors by a dual-targeted drug delivery system. Role: PI. 2018-2021
  • Grant reviewer: NIH Special Emphasis Panel ZRG1 BST-F (80), 2019; The Israel Science Foundation, 2018; Czech Science Foundation, 2017
  • Controlled Release Society (CRS) T. Nagai Postdoctoral Research Achievement Award, 2014
  • American Cancer Society-Ellison Foundation Postdoctoral Fellowship, 2013
  • AAPS Graduate Student Symposium Award in Biotechnology, 2009
  • University of Tennessee Student Travel Award, 2009
  • AAPS Travel Awards in Biotechnology, 2008 & 2009

Patents

  • Zhu L, Perche F, Torchilin VP, “Copolymers for the delivery of drugs into cells”, November 30, 2012 (U.S. No. 61/731,951 & International No. PCT/US2013/072216)
  • Zhu L, Torchilin VP, “System for delivery of siRNA and co-delivery of siRNA and drug into MMP-expressing cells” November 4, 2013 (U.S. No. 61/899,511)

Representative Publications

  • Zhu L, Ye Z, Cheng K, Miller DD and Mahato RI*, Site-specific Delivery of Oligonucleotides to Hepatocytes after Systemic Administration. Bioconjugate Chemistry, 2008, 19(1), 290-298.
  • Zhu L, Huo Z, Wang L, Tong X, Xiao Y, Ni K*, Targeted Delivery of Methotrexate to Skeletal Muscular Tissue by Thermosensitive Magnetoliposomes, International Journal of Pharmaceutics, 2009, 370(1-2),136-143.
  • Zhu L, Mahato R*, Targeted Delivery of siRNA to Hepatocytes and Hepatic Stellate Cells by Bioconjugation, Bioconjugate Chemistry, 2010, 21(11), 2119-2127.
  • Zhu L, Kate P, Torchilin VP*, Matrix Metalloprotease 2-responsive Multifunctional Liposomal Nanocarrier for Enhanced Tumor Targeting, ACS Nano, 2012, 6 (4), 3491–3498.
  • Wu H, Zhu L, Torchilin, VP*, pH-Sensitive Poly(histidine)-PEG/DSPE-PEG Copolymer Micelles for Cytosolic Drug Delivery, Biomaterials, 2013, 34(4):1213-1222.
  • Zhu L, Wang T, Perche F, Taigind A, Torchilin VP*, Enhanced Anticancer Activity of Nanopreparation Containing a Novel MMP2-sensitive PEG-drug Conjugate and Cell-penetrating Moiety, PNAS, 2013, 110 (42), 17047-17052.
  • Perche F, Biswas S, Wang T, Zhu L, Torchilin VP*, Hypoxia-targeted siRNA Delivery, Angewandte Chemie, 2014, 53(13):3362-6.
  • Zhu L, Perche F, Wang T, Torchilin VP*, Matrix Metalloproteinase 2-sensitive Multifunctional Polymeric Micelles for Tumor-specific Co-delivery of siRNA and Hydrophobic Drugs, Biomaterials, 2014, 35 (13), 4213-4222.
  • Tu Y, Zhu L*, Enhancing Cancer Targeting and Anticancer Activity by a Stimulus-sensitive Multifunctional Polymer-drug Conjugate, Journal of Controlled Release, 2015, 212, 94-102.
  • Dai Z, Tu Y, Zhu L*, Multifunctional Micellar Nanocarriers for Tumor-targeted Delivery of Hydrophobic Drugs, Journal of Biomedical Nanotechnology, 2016, 12, 1199-1210.
  • Dai Z, Yao Q, Zhu L*, MMP2-sensitive PEG-lipid Copolymers: A New Type of Tumor-targeted P-glycoprotein Inhibitor, ACS Applied Materials & Interfaces, 2016, 8 (20), 12661-12673.
  • Yao Q, Gutierrez DC, Hoang NH, Kim D, Wang R, Hobbs C, Zhu L*, Efficient Codelivery of Paclitaxel and Curcumin by Novel Bottlebrush Copolymer-based Micelles, Molecular Pharmaceutics, 2017, 14 (7), 2378–2389.
  • Yao Q, Dai Z, Choi JH, Kim D, Zhu L*, Building stable MMP2-responsive multifunctional polymeric micelles by an all-in-one polymer-lipid conjugate for tumor-targeted intracellular drug delivery, ACS Applied Materials & Interfaces, 2017, 9 (38), 32520–32533.
  • Yao Q, Choi JH, Dai Z, Wang J, Kim D, Tang X, Zhu L*, Improving tumor specificity and anticancer activity of dasatinib by dual-targeted polymeric micelles, ACS Applied Materials & Interfaces, 2017, 9 (42), 36642–36654.
  • Wang J, Lee JS, Kim D, Zhu L*, Exploration of Zinc Oxide Nanoparticles as a Multi-target and Multi-functional Anticancer Nanomedicine, ACS Applied Materials & Interfaces, 2017, 9 (46), 9971–39984.
  • Yao Q, Kou L, Tu Y, Zhu L*, MMP-responsive “smart” drug delivery and tumor targeting, Trends in Pharmacological Sciences, 2018, 39 (8), 766-781. (Cover Article)
  • Liu Y, Zhi D, Wang J, Tu Y, Zhu L*, Folate-targeted pH-sensitive bortezomib conjugates for cancer treatment, Chemical Communications, 2019, 55, 4254-4257.
  • Yao Q, Liu Y, Kou L, Tu Y, Tang X, Zhu L*, Tumor-targeted drug delivery and sensitization by MMP2-responsive polymeric micelles, Nanomedicine: Nanotechnology, Biology and Medicine, 2019,19, 71-80.

Complete List of Published Work:

https://www.ncbi.nlm.nih.gov/sites/myncbi/12gZubvuq1VQX/bibliography/46795826/public/?sort=date&direction=ascending .

Google Scholar:

https://scholar.google.com/citations?user=iNqdyjMAAAAJ&hl=en