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Erxi Wu

Erxi Wu
Erxi Wu, PhD

Associate Professor of Pharmaceutical Sciences

Contact

Texas A&M Irma Lerma Rangel School of Pharmacy
Mail Stop 1114 159 Reynolds Medical Bldg.
College Station , TX 77843
erxiwu@tamu.edu
Phone: 254.724.3785
Fax: 254.724.5779

Education and Training

  • Harvard Medical School , Instructor in Pediatrics, 2008
  • Harvard-MIT Division of Health Sciences and Technology, Research Fellow (NLM fellowship) in Health Sciences and Technology, 2005-2007
  • Children’s Hospital Boston, Harvard Medical School Staff Scientist and faculty member, 2005-2008
  • Dana-Farber Cancer Institute, Harvard Medical School , Research Associate in Medicine, 1998-2004
  • Massachusetts Institute of Technology (MIT) , Special Graduate Student in Modern Medicine, 2007-2008
  • Sheffield University Medical School , Ph.D. students in Human Metabolism and Clinical Biochemistry, 1995-1998

Research Interests

  • Cancer (brain tumors, neuroblastoma, pancreatic cancer, etc.) therapeutics targets, cancer stem cell biology
  • Therapeutics of neurodegenerative diseases
  • Blood biomarkers in cancer and other diseases
  • Drug binding targets, drug discovery, and natural products; Pharmacogenomics

Awards, Recognition and Service

  • President, the International Association of Biological and Medical Research (IABMR), 2002-2003)
  • President, Sino-American Pharmaceutical Professional Association-New England (SAPA-NE) , 2003-2004)
  • Vice President, Sino-American Pharmaceutical Professional Association (SAPA), 2003-2004
  • Guest Editor, Special Issue (Hot Topic), Current Medicinal Chemistry, 2002-2003
  • Invited Speaker, Shanghai 2004 Bio-Forum/Tri-Conferences, 2004
  • Outstanding Leadership Award, IABMR, 2005
  • Board Director of Chinese-American BioMedical Association (CABA), 2007-present
  • Editor-in-Chief, Newsletters, Association of Chinese Americans in Cancer Research (ACACR), 2017-present
  • Pioneer Award, Chinese-American BioMedical Association 10th Annual Conference, 2017
  • Ad Hoc Reviewer for over 50 scientific journals, e.g., Science Advances, Cancer Research, etc.

Representative Publications

  • Li J, Qi D, Hsieh TC, Huang JH, Wu JM, Wu E*. Trailblazing perspectives on targeting breast cancer stem cells. Pharmacology & Therapeutics. Jan 7. 2021. doi: 10.1016/j.pharmthera.2021.107800.
  • Ding X, Wang XX, Xia D, Liu H, Tian H, Fu Y, Chen Y, Qin C, Wang J, Xiang Z, Zhang Z, Cao Q, Wang W, Li J, Wu E, Tang B, Ma M, Teng J, Wang X. Impaired meningeal lymphatic drainage in patients with idiopathic Parkinson’s disease. Nature Medicine. Jan 18, 2021. doi:10.1038/s41591-020-01198-1.
  • Li Y, Burgman B, Khatri I, Pentaparthi S, Su Z, McGrail D, Li Y, Wu E, Eckhardt G, Sahni N, Yi SS. e-MutPath: Computational modelling reveals the functional landscape of genetic mutations rewiring interactome networks. Nucleic Acids Research. Nov 19, 2020. doi: 10.1093/nar/gkaa1015.
  • Ding X*, Zhou L, Jiang X, Liu H, Yao J, Zhang R, Laing D, Wang F, Ma M*, Tang B, Wu E*, Teng J*, Wang X*. Propagation of pathological α-synuclein from the urogenital tract to the brain initiates MSA-like syndrome. iScience. Jun 26; 23(6): 101166. 2020. doi: 10.1016/j.isci.2020.101166.
  • Wang X, Ma M, Zhou L, Jiang X, Hao M, Teng RKF, Wu E, Teng J, Tang B, Li J, Ding X. Autonomic ganglionic injection of α-synuclein fibrils as a model of pure autonomic failure α-synucleinopathy.  Nature Communications. Feb 18, 2020. doi: 10.1038/s41467-019-14189-9
  • Wang F*, Zhou S, Qi D, Xiang S, Wong ET, Wang X, Fonkem E, J Yang, Hsieh T, Kirmani B, Shabb JB, Wu JM, Wu M, Huang JH*, Yu W*, Wu E*. Nucleolin is a functional binding protein for salinomycin in neuroblastoma stem cells. Journal of the American Chemical Society. Jan 28, 2019. doi: 10.1021/jacs.8b12872.
  • Wang F*, Zheng Z, Guan J, Qi D,  Zhou S, Shen X, Wang F, Wenkert D, Krmanil B, Solouki T, Fonkem E, Wong ET, Huang JH*, Wu E*. Identification of a panel of genes as a prognostic biomarker for glioblastoma. EBioMedicine. Oct 16, 2018. doi: 10.1016/j.ebiom. 2018.10.024.
  • Li X, Wang Z, Ma Q, Xu Q, Liu H, Duan W, Lei J, Ma J, Wang X, Lv S, Han L, Li W, Guo J, Guo K, Zhang D, Wu E, Xie K. Sonic hedgehog paracrine signaling activates stromal cells to promote perineural invasion in pancreatic cancer. Clinical Cancer Research. Aug 15; 20(16):4326-38. 2014. doi: 10.1158/1078-0432.CCR-13-3426.
  • Zhang D, Ma Q*, Wang Z, Zhang M, Guo K, Wang F, Wu E*. β2-adrenoceptor blockage induces G1/S phase arrest and apoptosis in pancreatic cancer cells via Ras/Akt/NFκB pathway. Molecular Cancer. Nov 26, 2011. doi: 10.1186/1476-4598-10-146.
  • Zhang H, Bajraszewski N#, Wu E#, Wang H, Moseman AP, Dabora SL, Griffin JD, Kwiatkowski DJ. PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR. Journal of Clinical Investigation. 2007 Mar;117(3):730-738. 2007. (#equal contribution). doi: 10.1172/JCI28984.

For a complete list of publications and citations click here:
https://www.ncbi.nlm.nih.gov/myncbi/1879uTMkmytQu/bibliography/public/
https://scholar.google.com/citations?user=VNKRIF0AAAAJ&hl=en