Zhenyu Li
Professor of Pharmaceutical Sciences
Contact
Texas A&M Irma Lerma Rangel School of Pharmacy
1010 W. Ave. B
Kingsville,
TX
78363
Zli21@tamu.edu
Phone: 979.436.0264
Education and Training
- University of Illinois at Chicago, Chicago, Illinois, Postdoctoral fellow in Pharmacology, 1999-2003
- Soochow University, College of Medicine, Suzhow, Jiangsu, China, PhD in Hematology, 1994-1997
- Nantong University, College of Medicine, Nantong, Jiangsu, China, MS, 1991-1994
- Nantong University, College of Medicine, Nantong, Jiangsu, China, MD (eqv.), 1984-1989
Research Interests
- Platelet signaling; Mechanism of thrombosis and hemostasis; Crosstalk between inflammation and thrombosis; Role of platelets in cancer
Awards, Recognition and Service
- 2012 4th Biennial National IDeA Symposium of Biomedical Research Excellence (NISBRE) (NIH), Young Investigator Award
- 2009 ATVB Kenneth M. Brinkhous Young Investigator Prize in Thrombosis (Finalist)
- 2004 AHA Scientist Development Grant Award (National)
- 2001 AHA Midwest Affiliate, Postdoctoral Fellowship Award
- 2001 ASH (The American Society of Hematology) Travel Award
- 2000 ASH (The American Society of Hematology) Travel Award
- 1996 Upjohn Prize, Suzhou Pharmaceutical Co. Upjohn
Patents
- Li, Z; Xiang, B; Zhang, Z. Storage of Platelets. K075-0002USP1, filed on March 21,2018
Representative Publications
Wei Y, Yang L, Pandeya A, Cui J, Zhang Y, and Li Z. Pyroptosis-Induced Inflammation and Tissue Damage. J Mol Biol. 2021, 2021 Oct 13;167301. PMID: 34653436Review
Zhang Y, Cui J, Zhang G, Wu C, Abdel-Latif A, Smyth SS, Shiroishi T, Mackman N, Wei Y, Tao M, Li Z. Inflammasome activation promotes venous thrombosis through pyroptosis. Blood Adv. 2021 Jun 22;5(12):2619-2623. PMID: 34152402
Wu C, Lu W, Zhang Y, Zhang G, Shi X, Hisada Y, Grover S, Zhang X, Li L, Xiang B, Shi J, Li XA, Daugherty A, Smyth SS, Kirchhofer D, Shiroishi T, Shao F, Mackman N, Wei Y, and Li Z. Inflammasome Activation Triggers Blood Clotting and host death through Pyroptosis. Immunity 2019, June 19, 50:1-11. PMID: 31076358
Xiang B, Zhang Z, Ye S, Zhang R, Huang C, Liu J, Tao M, Ruan C, Smyth SS, Whiteheart SW, Li Z. Characterization of a novel integrin binding protein, VPS33B, which is important for platelet activation and in vivo thrombosis and hemostasis. Circulation, 2015,132(24):2334-44. PMID: 26399659
Xiang B, Zhang G, Guo, L, Li XA, Morris AJ, Daugherty A, Whiteheart SW, Smyth SS, and Li Z. Platelets protect from septic shock by inhibiting macrophage-dependent inflammation via the cyclooxygenase 1 signaling pathway. Nat Commun. 2013, 4:2657. PMID: 24150174.
Han J, Zhang G, Welch E, Ying Liang, Jian Fu, Vogel SM, Lowell CA, Du X, Cheresh DA, Malik AB, and Li Z. A distinct role for Lyn kinase in maintaining endothelial integrity and barrier function. Blood 2013, 22(25):4140-9. Highlighted as the subject of an “Inside Blood” commentary. PMID: 24108461
Zhang G, Xiang B, Dong A, Skoda RC, Daugherty A, Smyth SS, Du X, Li Z. Biphasic roles for soluble guanylyl cyclase in platelet activation. Blood 2011, 118(13):3670-9. PMID: 21803853
Li Z, Xi X, Gu, M, Feil R, Ye RD, Eigenthaler M, Hofmann F, and Du X. A stimulatory role for cGMP-dependent protein kinase in platelet activation. Cell 2003, 112: 77-86. PMID: 12526795