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Mahua Choudhury

Mahua Choudhury
Mahua Choudhury, PhD

Associate Professor of Pharmaceutical Sciences

Co-Director of Center for Microencapsulation and Drug Delivery

Contact

Mail Stop 1114
159 Reynolds Medical Building
College Station, TX 77843-1114
drmc@tamu.edu
Phone: 979.436.0773
Fax: 313.436.0087
Choudhury's Lab

Biography

CLICK BELOW TO VISIT CHOUDHURY'S LAB WEBSITE
CHOUDHURY'S LAB 

Choudhury-lab-.pngOngoing projects:

Lab is involved in several research projects related to the area of metabolism as it interacts with epigenetics. The research is currently emphasized on the

(1) Biology of Disease – Identifying and understanding molecular errors leading to metabolic syndrome and pregnancy complications at basic, translational, and clinical level

(2) Molecular Diagnostics – Developing non-invasive epigenetic markers and point of care diagnostic for diabetes, obesity, and preeclampsia as early as first trimester

(3) Nutritional or RNA therapeutic approaches that modulate or correct molecular errors in disease.

Project 1: Effect of Western Diet on Epigenetic and Non-coding RNA Regulation in Metabolic Syndrome and Transgenerational Inheritance (NAFLD/Atherosclerosis/Adipogenesis)

Project 2: Effect of Endocrine Disruptors on Epigenetics and Long non coding RNA in Metabolic syndrome (NAFLD/Atherosclerosis/Adipogenesis)

Project 3: Nutraceuticals in Disease Prevention (microRNA, HAT, and HDACs perspective- NAFLD/Atherosclerosis/Adipogenesis)

Project 4: Stem cell regulation, therapy, and microbiome in metabolic diseases

Project 5: Early first trimester epigenetic and microRNA Biomarkers in preeclamptic patients and reversal

Project 6: A Sensitive miRNA Tool for prediction of preeclampsia

Project 7: Aging and metabolic disorders: A vicious cycle

Project 8: Antioxidants infused hydrogel

Project 9: Epigenetic and miRNA biomarkers in noninvasive human samples

Project 10: Social disparity in birth defect and epigenetic regulation

Project 11: Epigenetic regulation in iPSC and HSC

Interview by KAGS NBC over Patented Preeclampsia Biomarkers

 

projects.jpg

 

 patent 1

https://patents.google.com/patent/US11291750B2/en

patent 2

https://patents.google.com/patent/US11344121B2/en

 

 

 

Education and Training

  • University of Colorado, Aurora, Colorado, Research Instructor of Pediatrics, Neonatology, September 2011-September 2012
  • University of Colorado, Aurora, Colorado, Postdoctoral Fellow of Pediatrics, Neonatology, August 2008-August 2011
  • University of Missouri-Columbia, Columbia, Missouri, PhD, Medical Pharmacology, 2008
  • University of Calcutta, India, Master of Science in Molecular Biology, Biophysics & Genetics, 2001
  • University of Calcutta, India, Bachelor of Science in Zoology, Botany, Chemistry, 1999

Research Interests

  • Prediction of disease risk
  • Genes and the environment
  • Pathology

Teaching Interests

  • Principles of drug action
  • Endocrinology

Representative Publications

  • Choudhury, M., & Friedman, J. E. Epigenetics and microRNAs in preeclampsia. Clinical and experimental hypertension, vol. 34,5 (2012): 334-41. doi:10.3109/10641963.2011.649931 PMID: 22468840
  • Choudhury, M., & Friedman, J. E. Obesity: childhood obesity--methylate now, pay later?. Nature reviews. Endocrinology, 7(8), 439–440. (2011). doi: 10.1038/nrendo.2011.102 PMID: 21691305
  • Choudhury, M., Jonscher, K. R., & Friedman, J. E. Reduced mitochondrial function in obesity-associated fatty liver: SIRT3 takes on the fat. Aging, 3(2), 175–178. (2011). doi: 10.18632/aging.100289. PMID: 21386135
  • Choudhury, M., Pandey, R. S., Clemens, D. L., Davis, J. W., Lim, R. W., & Shukla, S. D. Knock down of GCN5 histone acetyltransferase by siRNA decreases ethanol-induced histone acetylation and affects differential expression of genes in human hepatoma cells. Alcohol, 45(4), 311–324. (2011). doi: 10.1016/j.alcohol.2010.12.003. PMID: 21367571
  • Ash, G. I., Kim, D., & Choudhury, M. Promises of Nanotherapeutics in Obesity. Trends in endocrinology and metabolism: TEM, 30(6), 369–383. (2019). doi: 10.1016/j.tem.2019.04.004. PMID: 31126754
  • Kabekkodu, S. P., Gladwell, L. R., & Choudhury, M. The mitochondrial link: Phthalate exposure and cardiovascular disease. Biochimica et biophysica acta. Molecular cell research, 1871(4), 119708. (2024). doi: 10.1016/j.bbamcr.2024.119708. PMID: 38508420
  • Powell, C. A., & Choudhury, M. Advancing metabolism research to overcome low litter survival in metabolically stressed mice. American journal of physiology. Endocrinology and metabolism, 317(2), E261–E268. (2019). doi: 10.1152/ajpendo.00024.2019. PMID: 31084500.
  • Schechinger, M., Marks, H., Mabbott, S., Choudhury, M., & Cote', G., A SERS approach for rapid detection of microRNA-17 in the picomolar range. The Analyst, 144(13), 4033–4044. (2019). doi: 10.1039/c9an00653b. PMID: 31143920.
  • Zhang, J., & Choudhury, M. Benzyl Butyl Phthalate Induced Early lncRNA H19 Regulation in C3H10T1/2 Stem Cell Line. Chemical research in toxicology, 34(1), 54–62. (2021). doi: 10.1021/acs.chemrestox.0c00129. PMID: 33395283.
  • Zhang, J., Kay, M. K., Park, M. H., Meruvu, S., Powell, C., & Choudhury, M. LncRNA DLEU2 regulates sirtuins and mitochondrial respiratory chain complex IV: a novel pathway in obesity and offspring's health. International journal of obesity, 46(5), 969–976. (2022). doi: 10.1038/s41366-022-01075-6. PMID: 35058572.
  • Zhang, J., Powell, C., Meruvu, S., Sonkar, R., & Choudhury, M. Pyrroloquinoline quinone attenuated benzyl butyl phthalate induced metabolic aberration and a hepatic metabolomic analysis. Biochemical pharmacology, 197, 114883. (2022). doi: 10.1016/j.bcp.2021.114883. PMID: 34971587.